PA2G4 antibody (AA 1-394)

Catalog No. ABIN5776098

This Mouse Monoclonal antibody specifically detects PA2G4 in WB, ELISA, IF, FACS and ICC. It exhibits reactivity toward Human.

Quick Overview for PA2G4 antibody (AA 1-394) (ABIN5776098)

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PA2G4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: AT5E7

Product Details anti-PA2G4 Antibody

Binding Specificity: AA 1-394

Purpose: Human PA2G4 antibody

Purification: Purified

Immunogen: Recombinant human PA2G4 (1-394aa) purified from E. coli

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for PA2G4

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Alternative Name: PA2G4

Background: PA2G4 may play a role in a ERBB3-regulated signal transduction pathway and seems be involved in growth regulation. This protein acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Also, this protein Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity, and binds RNA. The protein is associated with 28S, 18S and 5. 8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA, that may be involved in regulation of intermediate and late steps of rRNA processing, and may be involved in ribosome assembly. The protein mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity), and regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

NCBI Accession: NP_006182

Pathways: Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades